Localized mRNA translation is a biological process that allows mRNA to be translated on‐site, which is proposed to provide fine control in protein regulation, both spatially and temporally within a cell. We recently reported that Vasa, an RNA‐helicase, is a promising factor that appears to regulate this process on the spindle during the embryonic development of the sea urchin, yet the detailed roles and functional mechanisms of Vasa in this process are still largely unknown. In this review article, to elucidate (...) these remaining questions, we first summarize the prior knowledge and our recent findings in the area of Vasa research and further discuss how Vasa may function in localized mRNA translation, contributing to efficient protein regulation during rapid embryogenesis and cancer cell regulation. (shrink)

RESUMEN Nos adentramos en esos procesos de subjetivación en los que el músico de jazz experimenta en sí otras formas de corporalidad, que se dirimen entre sujeción a esquemas y ruptura de los corsés por una teatralidad en escena. Aparentemente, en la improvisación prima lo subversivo y la reificación del músico como autor libre; sin embargo, observamos empíricamente una corporalidad plural que trasciende el espacio de la escena y que facilita que todos los actores intervengan en el proceso de creación. (...) Hallamos una red de solidaridad que desplaza continuamente los puntos fijos por donde transita la música; así, cuando a un músico le falta el aire, su compañero le da el relevo. Si lo fundamental en la praxis de la música son las continuas alternativas que ofrece, concluimos con una reflexión ética sobre la naturaleza transitoria de la música y su temporalidad kairológica, en la que el músico, sintiendo la brevedad del instante de la nota que muere cuando nace, se reencuentra con lo insignificante de la que está hecha su condición humana. ABSTRACT We enter these processes of subjectivation in which the jazz musician experiences in himself other forms of corporeality, which are settled between subjection to schemes and breakup of the corsets by a theatricality on stage. Apparently, in improvisation what is subversive and the reification of the musician as a free author take priority; nevertheless, we empirically observe a plural corporeality that goes beyond the space of the scene and that facilitates that all the actors take part in the process of creation. We found a solidarity network that continuously displaces the fixed points where music circulates; thus, when a musician is short of breath, his partner takes over. If what is fundamental in the praxis of music is the continuous alternatives it offers, we conclude with an ethical reflection on the transitory nature of music and its kairological temporality, in which the musician, feeling the briefness of the instant of the note that dies when it is born, joins the insignificance of his human condition. (shrink)

La sostenibilidad implica una nueva forma de comprender el mundo y organizar las relaciones. Nutrida en valores que se dirigen al equilibrio y desarrollo humano, instala la necesidad de actualizar los modelos educativos en Educación Superior y constituirse en aporte al desarrollo sostenible. En ese contexto, la universidad Bernardo O’Higgins, considera necesario compilar aquellas fortalezas del socioconstructivismo y el modelo dialógico, como formas de relación en y para el aprendizaje en comunidad. Fortaleciendo el análisis de la formación integral desde un (...) enfoque cualitativo. Dando cuenta de cómo mejoran los procesos al participar en espacios como las Comunidades de Aprendizaje en Red. (shrink)

BackgroundThe psychological burden possibly deriving from not immediately undergoing radical treatment for prostate cancer could be a potential disadvantage of active surveillance, especially in the eve of some relevant clinical exams [i.e., re-biopsy, prostate-specific antigen test, and medical examination]. Even if it is known from the literature that the majority of PCa men in AS do not report heightened anxiety, there is a minority of patients who show clinically significant levels of anxiety after diagnosis. The present study aimed to investigate (...) if demographic, clinical, and psychological variables at the entrance in AS were associated with the risk of developing clinically significant PCa-related anxiety 2 months before the first re-biopsy and to offer psychological support to improve quality of life.Materials and MethodsA total of 236 patients participated in the PCa Research International: AS protocol and in PRIAS-QoL study. Demographic/clinical features, health-related QoL domains, coping with cancer, PCa-related anxiety [Memorial Anxiety Scale for PCa ], personality traits, and decision-making-related factors were assessed at T0. MAX-PC was also administered at T1. PCa-related anxiety at T1 was considered to be of clinical significance if the MAX-PC score was ≥1.5. Multivariable logistic regression coupled to bootstrap was used to detect factors associated with high levels of anxiety.ResultsThe median age was 64.4 years. Fifty-six patients reported MAX-PC total score above the cutoff. Three factors were associated with a high level of PCa anxiety at T1: anxious preoccupation [odds ratio = 4.36], extraversion, and prostate-related symptoms. Physical well-being was associated with a low PCa anxiety subscale ; neuroticism and functional well-being were associated with PSA anxiety. Neuroticism and helplessness/hopelessness were associated with fear of progression.ConclusionOnly a partial portion of the sample experienced significant levels of anxiety after 10 months. Psychological assessment should be routinely conducted to detect risk factors for increased anxiety, offering tailored psychological interventions aimed at promoting interpersonal awareness and emotional well-being. (shrink)

In Older Adults (OAs), Electroencephalogram (EEG) slowing in frontal lobes and a diminished muscle atonia during Rapid Eye Movement sleep (REM) have each been effective tracers of Mild Cognitive Impairment (MCI), but this relationship remains to be explored by non-linear analysis. Likewise, data provided by EEG, EMG (Electromyogram) and EOG (Electrooculogram)—the three required sleep indicators—during the transition from REM to Non-REM (NREM) sleep have not been related jointly to MCI. Therefore, the main aim of the study was to explore, with (...) results for Detrended Fluctuation Analysis (DFA) and multichannel DFA (mDFA), the Color of Noise (CN) at the NREM to REM transition in OAs with MCI vs. subjects with good performances. The comparisons for the transition from NREM to REM were made for each group at each cerebral area, taking bilateral derivations to evaluate interhemispheric coupling and anteroposterior and posterior networks. In addition, stationarity analysis was carried out to explore if the three markers distinguished between the groups. Neuropsi and the Mini-Mental State Examination (MMSE) were administered, as well as other geriatric tests. One night polysomnography was applied to 6 OAs with MCI (68.1 ± 3) and to 7 subjects without it (CTRL) (64.5 ± 9), and pre-REM and REM epochs were analyzed for each subject. Lower scores for attention, memory and executive funcions and a greater index of arousals during sleep were found for the MCI group. Results confirmed that EOGs constituted significant markers of MCI, increasing the CN for the MCI group in REM sleep. The CN of the EEG from the pre-REM to REM was higher for the MCI group vs. the opposite for the CTRL group at frontotemporal areas. Frontopolar interhemispheric scaling values also followed this trend as well as right anteroposterior networks. EMG Hurst values for both groups were lower than those for EEG and EOG. Stationarity analyses showed differences between stages in frontal areas and right and left EOGs for both groups. These results may demonstrate the breakdown of fractality of areas especially involved in executive functioning and the way weak stationarity analyses may help to distinguish between sleep stages in OAs. (shrink)

Resumen Los filósofos sentimentalistas escoceses David Hume y Adam Smith proponen dos estrategias distintas para restringir las tendencias egoístas de la naturaleza humana. A pesar de las evidentes similitudes de sus propuestas morales, Smith encuentra dentro del ser humano la capacidad para transformar sus pasiones parciales y aspirar hacia ideales de perfección. El sentimentalismo de Hume, en cambio, no permite la autotransformación de la persona, y debe apoyarse en convenciones sociales para manipular y redirigir los impulsos egoístas desde fuera. Ambos (...) logran su objetivo. Pero mientras Hume se conforma con una moral funcional para la vida social, Smith abre una nueva dimensión de desarrollo para el ser humano.The Scottish sentimentalist philosophers David Hume and Adam Smith suggest different strategies for restricting and accommodating human selfish tendencies. In spite of the obvious similarities of their moral proposals, Smith finds within the human being the capacity to transform his partial passions and to aspire to ideals of perfection. In contrast, Hume's sentimentalism does not allow for self-transformation, and must rely on social conventions to manipulate and redirect selfish impulses from without. Both attempts achieve their goal. However, while for Hume peaceful social interaction seems to be the only aim of morality; for Smith morality also opens a new dimension of development for the human being. (shrink)

The aim of this paper lies in characterizing the explanations and models used in the field of evolutionary developmental biology throughout its history. While manipulative experiments in controlled conditions have been useful to set the bases of the discipline and are still routinely performed, this approach supposes a tension between the reliability and the representativity of the conclusions. Given the recent changes in the understanding of evolutionary phenomena, different authors currently emphasize the need of avoiding excessive simplifications in experimental approaches, (...) incorporating the complexity of the analyzed systems as a relevant trait in the study of biological diversity. On the other hand, the fragile and contingent nature of evolutionary processes and the impossibility of intervening some of these phenomena underscore the importance of non-manipulative models that allow the elucidation of how-possibly mechanisms. We argue that a pluralism characterized by the integration of different kinds of explanations, models and metaphors used in evo-devo allows to exploit their respective advantages, favours interdisciplinarity and can contribute to form a representative description of evolutionary processes without relinquishing the local and detailed study of actual mechanisms. (shrink)

en las últimas décadas la bioética se ha vuelto un tema crucial para la Iglesia. La dinámica propia de la técnica, que se auto-propulsa y avanza con independencia de criterios éticos, amenaza de modo inminente la dignidad humana. En la actualidad ya existe la posibilidad de producir artificialmente seres humanos, incluso sin la mediación de gametos. Pero lo que no existe son los índices para reconocer cuándo una célula intervenida sigue siendo sólo una célula -eventualmente pluripotencial y por tanto con (...) grandes promesas terapéuticas; o cuando ya es una célula totipotencial, un cigoto, un organismo humano: una persona. Ciencia, filosofía y teología, como se mostrará en este artículo, se unen en la reflexión bioética para encontrar de modo urgente esas señales; puesto que la biotecnología sigue avanzando, y hay de tomar posición sobre sus descubrimientos. La Iglesia no puede callar frente a una posible producción artificial, instrumentalización y destrucción de personas; que aunque estén en su fase unicelular y hayan llegado al mundo como artefactos, siguen siempre siendo el reflejo del Rostro de Dios. (shrink)

El propósito, sistematizar la estrategia pedagógica de formación y evaluación de la investigación, orientada a estudiantes de pregrado vinculados a un semillero virtual, que conduce a la comunicación y divulgación académica-científica. Se utilizó una metodología cualitativa a partir del modelo para la sistematización de experiencias que describe cinco momentos (planeación; diseño; implementación; tutorización y seguimiento evaluativo). Demostró que la formación para la investigación requiere de la gestión del conocimiento aspectos relacionados con: personas, pedagogía, didáctica, recursos tecnológicos, procesos, técnicas e instrumentos (...) de evaluación alternativa y herramientas cognitivas, integradas a un entorno virtual de aprendizaje (EVA). Estos constituyen Indicadores de calidad. (shrink)

En este ensayo respondemos a la pregunta: ¿Qué posibilidades, obstáculos y tensiones ofrece “el don de dar vida” a la producción de la mujer como persona en México?, para ello analizamos una expresión común y de uso popular en México: “el don de dar vida”. Identificamos que la expresión tiene similitudes, aunque también diferencias con “el don” del que habló Marcel Mauss. Una de las diferencias es que actualmente la expresión “el don de dar vida” se usa en las culturas (...) híbridas. Mientras el don del que habla Mauss es propio de sociedades colectivistas. En las conclusiones presentamos el porqué de estas diferencias, y los efectos que generan para la producción del sujeto mujer. (shrink)

La comunicación analiza la importancia del derecho a la participación en los procedimientos de protección a la infancia, especialmente en los casos de los niños y niñas migrantes no acompañados al ser nuevos actores sociales. Estas niñas y niños son autónomos, poseen su propio plan vida, en el que se incluye su propio plan migratorio, y actúan de una manera distinta dentro de la sociedad. Tienen derecho a participar dentro de los sistemas de protección y que, por tanto, estos sistemas (...) deberían tener en cuenta sus particularidades como nuevos actores sociales, para que se logre una correcta protección de sus derechos. (shrink)

This article shows part of the results of a research project: The Impact of Social Change in Higher Education Staff Professional Life and Work (Spanish Ministry of Science and Innovation, SEJ2006-01876). The main aim of this project was to explore and understand how scholars establish a dialogue, resist, adapt themselves or adopt changes, in the process of constructing their professional identities. As the members of the research team were scholars ourselves, teaching and carrying out research in Spanish universities, we started (...) this research by writing our own autoethnographies. As a result, we developed nine autoethnographies which give a complex and in-depth account of senior and junior scholars' journeys into their process of constructing their professional identity and working lives in a rapidly changing world. This article starts by giving a context to the research project and arguing the need for conducting autoethnographies. It goes on to discuss the process itself of writing autoethnographies in the context of a given research project. We then refer to the topics which have a bearing on how we have learnt to become scholars: our experience as university students, the beginning of the academic career, relationships with others, and the consequences of the mark of gender. We conclude with the lessons learnt around the dilemmas on writing autoethnographies. (shrink)

El artículo presenta avances de una investigación realizada en San Carlos de Bariloche por un equipo de profesoras y estudiantes del IFDC Bariloche: "Condiciones que favorecen y obstaculizan la inclusión educativa de jóvenes y adultos/as con discapacidad intelectual en educación primaria, secundaria y técnico-profesional en San Carlos de Bariloche". Se comparten aportes jurídico-normativos, dimensiones del marco teórico, y avances a partir del análisis de entrevistas iniciales a equipos directivos, docentes, y a un estudiante con DI. Finalmente, se exponen facilitadores y (...) barreras para la inclusión educativa y social, y aportes para la discusión acerca de la temática. (shrink)

Pocos niegan hoy que el mercado, por sí sólo, es incapaz de generar espontáneamente una distribución equitativa de los recursos sociales. Para lograr una buena articulación entre capitalismo, mercado y democracia, se ha propuesto el reconocimiento de un nuevo derecho social: el Ingreso Básico Universal que, en su versión más extendida, supone un ingreso incondicional de subsistencia, pagado por el gobierno, de manera uniforme y en intervalos regulares, tanto a nacionales como a residentes permanentes. Aunque existen disputas sobre la incondicionalidad (...) de este ingreso, es decir, sobre si el beneficiario debe o no cooperar con su trabajo a la sociedad, lo cierto es que la propuesta del Ingreso Básico Universal tiene, al menos, tres importantes atractivos. Primero, que es probablemente la primera oportunidad real en la historia para reconocer el trabajo de cuidado que realizan las mujeres en todo el mundo gratuitamente. En segundo lugar, se trataría de una propuesta visionaria que permitirá responder a la previsible problemática generada por el llamado capitalismo cognitivo y la pérdida de trabajos derivada del desarrollo de la Inteligencia Artificial. Finalmente, el Ingreso Básico Universal sería una herramienta eficaz para paliar la actual crisis del desempleo y la precariedad laboral. (shrink)

We invited five Cavell scholars to write on this topic. What follows is a vibrant exchange among Paola Marrati, Andrew Norris, Jörg Volbers, Cary Wolfe and Thomas Dumm addressing the question whether, in the contemporary political context, Cavell’s skepticism and his Emersonian perfectionism amount to a politics at all.

El libro aborda las tensiones epistemológicas de la doble racionalidad a la que se ven enfrentados los estudiantes mapuches. Quienes, por un lado, construyen el conocimiento mediante el kimeltuwün, que de acuerdo a los kimches es un proceso de aprendizaje enseñanza que se configura entre una o más personas y que cuenta con cinco principios educativos clave: kümeyawael, yamüwael, küme che geael y kim che geael. Estos principios están orientados desde la naturaleza, el medio social y espiritual. Por otro lado, (...) los estudiantes, de origen mapuche, se ven enfrentados a una educación occidental de corte eurocéntrica, con un enfoque monocultural, que comprende a la educación como un proceso de enseñanza y aprendizaje, cuyo foco central es la reproducción de información. En este contexto se tensiona el aprendizaje, puesto que, la educación de la escuela no considera los saberes mapuches para la construcción de conocimiento, sin embargo la educación mapuche asume para si la educación occidental, logrando dos comprensiones: la escolar y la mapuche. (shrink)

At Universitat Politècnica de València, Meridies, an internship programme that places engineering students in countries of Latin America, is one of the few opportunities the students have to explore the implications of being a professional in society in a different cultural and social context. This programme was analyzed using the capabilities approach as a frame of reference for examining the effects of the programme on eight student participants. The eight pro-public-good capabilities proposed by Melanie Walker were investigated through semi-structured interviews. (...) The internship is an environment in which students can put into practice the knowledge they have acquired in undergraduate studies and to find practical relevance in what they studied. Occasionally, this also entails a critical questioning of what they have learned, a greater awareness of the limits of the contents of their studies and of the way things were taught, and interest in less explored issues that are closely linked to social justice. However, tensions can arise between the pro-public-good oriented perspectives of this programme, and a more instrumental vision. One way to overcome these tensions is to foster consideration of reflexivity, that is, the dynamic relationship between technology and society. To do so, the programme must create space before and during the internship, and upon the return of the students, to discuss and collectively reflect upon their lived experience. Additionally, it ought to engage supervisors in this educational journey, both at the university and in the host institutions, and also involve socially committed organisations in this task. (shrink)

Pregnancy presents some interesting challenges for the philosophy of embodied cognition. Mother and fetus are generally considered to be passive during pregnancy, both individually and in their relation. In this paper, we use the enactive operational concepts of autonomy, agency, individuation, and participation to examine the relation between mother and fetus in utero. Based on biological, physiological, and phenomenological research, we explore the emergence of agentive capacities in embryo and fetus, as well as how maternal agency changes as pregnancy advances. (...) We show that qualitatively different kinds of agency have their beginnings already in utero, and to what extent fetal and maternal movement modulate affectivity and individuation in pregnancy. We thus propose that mother and fetus are both agents who participate in pregnancy. Pregnancy then emerges as a relational developmental organization that anchors and holds its developing participants. We end the paper with reflections on ethical implications of this proposal, and suggestions for future research. (shrink)

«Obra en Blanco» es un libro sobre la obra temprana de Julio Enrique Blanco de la Rosa (1890-1986), un olvido más en la historia de la filosofía colombiana. Salvo en notas al margen, a Blanco no se lo encuentra en los estudios sobre la historia de la filosofía. Algunos han atribuido su desconocimiento a la incomprensión de un medio que no supo de su genialidad, otros creen que se debe a que su filosofía fue una necedad que consistió en poner (...) nuevos nombres a las viejas cosas. «Obra en Blanco» no intenta defender su genialidad o censurar a quienes lo han acusado de necedad: analiza y presenta una selección de un periodo juvenil de su obra, comprendido entre 1909-1920. Con ello sólo se busca aportar a la construcción de una historia de la filosofía nacional, y alimentar la discusión sobre la historia de la contribución filosófica de un hombre, cuyas páginas se encuentran aún en blanco. (shrink)

Una de las matrices que opera en la construcción roigeana de la Historia de las ideas latinoamericanas radica en la intención de seguir afirmando y haciendo explícito el “sentido” desde el cual se organiza, precisamente, el “a priori antropológico”, el que determina el valor axiológico como imposibl..

This article reflects on two contrasting intellectual profiles: the Argentinian university lecturer Ernesto Quesada and the Mexican intellectual José Vasconcelos, who visited Argentina in 1922. As we shall see, both define the University Reform in a contrasting way a few years after 1918. On the one hand, Quesada advocates conceiving the Reform as a key experience in order to make advances in the professionalisation of university teaching and research, autonomising these practices from politics. On the other hand, Vasconcelos resists disciplinary (...) specialisation and defends the construction of continental political leaderships, within the reformist movement, in line with the Mexican Revolution experience. Likewise, this article addresses certain points of contact between Vasconcelos and the Argentinian Ricardo Rojas who ideologically converge and also distance themselves from each other on their assessment of the Reform in the years that spanned the 1920s to 1930s. (shrink)

En este escrito presentamos los principales resultados de un trabajo de investigación realizado entre 2010 y 2012, que tuvo como uno de sus objetivos centrales analizar las representaciones de las condiciones objetivas de existencia asignadas a personajes de películas animadas infantiles. Se trabajó con tres producciones de gran consumo en el mercado mundial. El análisis realizado nos permite señalar que, a pesar de los cambios sociales que se produjeron a lo largo de casi 40 años, las películas infantiles tienden a (...) recuperar modos de representación históricamente legitimadas, que coadyuvan a la reproducción de sentidos y jerarquías dominantes. (shrink)

En 1982 salieron las circulares en las que el Consejo Superior de Investigaciones Científicas convocaba el Congreso Internacional sobre Semiótica e Hispanismo, celebrado en Madrid en 1983 y cuyos textos se han encontrado durante décadas entre los más citados de la Filología Hispánica internacional. Al cumplirse 30 años de aquel acontecimiento, entrevistamos al profesor del CSIC Miguel Ángel Garrido Gallardo, promotor del congreso, y le preguntamos por las claves, vistas con la perspectiva de los años transcurridos, de la teoría literaria (...) en lengua española, lo que constituyó entonces la cuestión fundamental de debate. (shrink)

El pensamiento ambiental, de tipología mesiánica, se caracteriza por el relativismo culturalista y el escepticismo autoritario en la fe y el mito de la naturaleza, y de un ser metafísico o religioso, que se introduce de forma simbólica, ya sea de manera inmanente o trascendente en las configuraciones simbólicas y por ende en las acciones. Es característico de dicho mesianismo su auto presentación en contra de la tecnología; sin diferenciar críticamente ciencia de técnica, y ambas categorías del instrumentalismo cosificante. Esta (...) corriente de mesianismo ambiental transforma las visiones críticas de las teoría de la acción comunicativa colocándolas acríticamente sobre la plataforma ideológica de la teología de la liberación latinoamericana, con un centramiento metafísico y antropológico, que se denominará para los propósitos argumentativos de este articulo: teología de la acción comunicativa. (shrink)

Traducción de A. A., Door de schaduwen bestormd. Reflecties op de controverse rond de oorlogsjaren van Lucebert (Atormentado por las sombras. Reflexiones respecto al debate sobre los años de guerra de Lucebert). Yi Fong Au y Tommy van Avermaete, red. Zaandam, 2019, Uitgeverij Oevers.

_ Source: _Volume 36, Issue 1, pp 63 - 77 At the basis of modern natural law theories, the concept of the _suum_, i.e. what belongs to the person, has received little scholarly attention despite its importance both in explaining and justifying not only the genealogy of property, but also that of morality and war. In this essay I focus on Grotius’s account of the _suum_ and examine what it is, what things it includes, what rights it gives rise to, (...) and how it is extended in the transition from the state of nature to civil society. I then briefly suggest that reviving this concept could help to illuminate the current discussion on the foundations of basic human rights, and to re-evaluate cases where these seem to clash with property rights. (shrink)

Vulval development in the Caenorhabditis elegans hermaphrodite represents a simple, genetically tractable system for studying how cell signaling events control cell fata decisions. Current models suggest that proper specification of vulval cell fates relies on the integration of multiple signaling systems, including one that involves a receptor tyrosine kinase (RTK)→Ras→mitogen activated protein kinase (MAPK) cascade and one that involves a LIN‐12/Notch family receptor. In this review, we first discuss how genetic strategies are being used to identify and analyze components that (...) control vulval cell fate decisions. We then describe the different signaling systems that have been elucidated and how they relate to one another. Finally, we highlight several recently characterized genes that encode positive regulators, negative regulators or potential targets of the RTK→Ras→MAPK cascade involved in vulval induction. (shrink)

ABSTRACT In this article, we propose strategies for capturing polemical regions in a corpus of posts from Twitter, setting out from a theoretical framework that emphasises a dialogic perspective. Based on these strategies, we provide entry points for analysing the materiality of the techno-discursive universe that circulates in digital environments. By producing this research corpus, we acquired a clearer understanding of elements that compose discursive images surrounding Diego Maradona in circulation on Twitter following the player’s death. Towards this aim, we (...) formulated and critically considered techniques for extracting and producing a digital research corpus by delimiting a discursive space on Twitter surrounding Maradona’s death. The results obtained pertain to the conditions for use of these platforms by discourse analysts, the cartography of the regions configured in this space and the clashes that become consolidated within them. (shrink)